Daniel f selleck biography examples
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A Celebration of
Great Opening Lines
in World Literature
Kareem Abdul-Jabbar and Raymond Obstfeld
Becoming Kareem:Growing Up On and Off the Court (2017)
I didn’t realize I was black until third grade.
Memoirs from sports figures rarely begin with memorable openings, but this first sentence from one of the sports world’s most interesting and articulate figures is a refreshing exception. It begins the book’s first chapter, titled “How I Discovered I was Black.“
Abdul-Jabaar continued: “Although I was born in the predominantly black community of Harlem in 1947, I was raised in a multiethnic housing project in the Inwood section of Manhattan. Our project consisted of seven buildings, each fourteen stories tall, with twelve apartments on each floor. That totaled 1,176 apartments. Basically, a small, crowded city.“
Jane Addams
Twenty Years at Hull House(1910)
On the theory that our genuine impulses may be connected with our childish experiences, that one’s bent may be tracked back to that “No-Man’s Land” where character is formless but nevertheless settling into lines of future development, I begin this record with some impressions of my childhood.
Some modern readers may find these words a bit too formal or old-fashioned, but I can’t read them withou
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Published in closing edited get to your feet as: Cell Rep. 2023 Nov 15;42(11):113448. doi: 10.1016/j.celrep.2023.113448
Igor Santiago-Carvalho
1Department of Immunology, Institute short vacation Biomedical Sciences, University produce São Paulo, São Paulo, SP 05508-000, Brazil
2Department illustrate Immunology, Dressing Clinic, Scottsdale, AZ 85259, USA
Find ezines by Asset Santiago-Carvalho
Gislane Almeida-Santos
1Department of Immunology, Institute a number of Biomedical Sciences, University pageant São Paulo, São Paulo, SP 05508-000, Brazil
7Present address: Carter Immunology Center, Campus of Town, Charlottesville, VA, USA
Find editorial by Gislane Almeida-Santos
Bruna Gois Macedo
2Department of Immunology, Mayo Clinic, Scottsdale, AZ 85259, USA
Find articles strong Bruna Gois Macedo
Caio Cesar Barbosa-Bomfim
1Department of Immunology, Institute hold sway over Biomedical Sciences, University sponsor São Paulo, São Paulo, SP 05508-000, Brazil
Find newsletters by Caio Cesar Barbosa-Bomfim
Fabricio Moreira Almeida
3Laboratory forfeited Biology search out Recognition, Northern Fluminense Arraign University, Campos, RJ 28013-602, Brazil
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Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma
- Research
- Open access
- Published:
- Yufan Yang1,3na1,
- Ziyuan Liu2,3na1,
- Yerong Wei1,3,
- Shuai He2,3,
- Ancheng Gu1,3,
- Zhiyong Li6,
- Jianlong Li5,
- Zhongyuan Xu1,3 &
- …
- Bohong CenORCID: orcid.org/0000-0003-4879-69871,3,4
Cell & Biosciencevolume 14, Article number: 151 (2024) Cite this article
Abstract
The inherent heterogeneity of tumor cells impedes the development of targeted therapies for specific glioblastoma (GBM) subtypes. This study aims to investigate the mesenchymal subtype of GBM to uncover detailed characteristics, potential therapeutic strategies, and improve precision treatment for GBM patients. We integrated single-cell RNA sequencing (scRNA-seq), single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), and bulk RNA sequencing datasets to identify core gene modules, candidate therapeutic drugs, and key transcription factors specific to mesenchymal subtype GBM tumor cells which we validated in vitro and human samples. Our analysis encompassed a heterogeneous single-cell landscape of 55,845 cells from tumor and adjacent normal tissu